Vaccination for highly pathogenic avian influenza (HPAI) has been implemented in China for a decade, however, the virus is still present in poultry.A series of recombinant Course a pied - Femme - Vetements - Chandail - Long sleeves vaccines, Re-1 to Re-7, have been developed and used, and Re-8 will also be used in clinical settings to prevent the prevailing flu strains.The question remains, when can China eradicate the disease? Here, we review the epidemiology of H5 HPAI along with the Sea Products development, usage and problems of vaccines.Further suggestions for controlling the disease in China are provided.